In vitro and in vivo comparisons of amphotericin B and N-D-ornithyl amphotericin B methyl ester.

N-D-Ornithyl amphotericin B methyl ester (N-D-ornithyl AmE) has a lower toxicity for animals than does amphotericin B (AmB), and peak serum levels can be achieved that are fourfold higher than those obtained with an equivalent dose of AmB. However, N-D-ornithyl AmE has one-fourth the in vitro activi...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Kobayashi, G S, Little, J R, Medoff, G
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1985
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC176265/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3994345/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.27.3.302
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