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The chemical stability of abasic RNA compared to abasic DNA

We describe the synthesis of an abasic RNA phosphoramidite carrying a photocleavable 1-(2-nitrophenyl)ethyl (NPE) group at the anomeric center and a triisopropylsilyloxymethyl (TOM) group as 2′-O-protecting group together with the analogous DNA and the 2′-OMe RNA abasic building blocks. These units...

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Main Authors: Küpfer, Pascal A., Leumann, Christian J.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1761435/
https://ncbi.nlm.nih.gov/pubmed/17151071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl948
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