Identification of a Novel Cyclic AMP-response Element (CRE-II) and the Role of CREB-1 in the cAMP-induced Expression of the Survival Motor Neuron (SMN) Gene

Spinal muscular atrophy, an autosomal recessive disorder, is caused by loss of the SMN1 (survival motor neuron) gene while retaining the SMN2 gene. SMN1 produces a majority of full-length SMN transcript, whereas SMN2 generates mostly an isoform lacking exon 7. Here, we demonstrate a novel cAMP-respo...

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Bibliografische gegevens
Hoofdauteurs: Majumder, Sarmila, Varadharaj, Saradhadevi, Ghoshal, Kalpana, Monani, Umrao, Burghes, Arthur H. M., Jacob, Samson T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2004
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1761111/
https://ncbi.nlm.nih.gov/pubmed/14742439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M308225200
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