Antagonist activities of mecamylamine and nicotine show reciprocal dependence on beta subunit sequence in the second transmembrane domain

1. We show that a portion of the TM2 domain regulates the sensitivity of beta subunit-containing rat neuronal nicotinic AChR to the ganglionic blocker mecamylamine, such that the substitution of 4 amino acids of the muscle beta subunit sequence into the neuronal beta4 sequence decreases the potency...

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Detalhes bibliográficos
Main Authors: Webster, J Christopher, Francis, Michael M, Porter, Julia K, Robinson, Gillian, Stokes, Clare, Horenstein, Ben, Papke, Roger L
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1760656/
https://ncbi.nlm.nih.gov/pubmed/10455283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702686
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