Binding of novel macrolide structures to macrolides-lincosamides-streptogramin B-resistant ribosomes inhibits protein synthesis and bacterial growth.

Dimethylation of adenine 2058 in 23S rRNA renders bacteria resistant to macrolides, lincosamides, and streptogramin B (MLS resistance), because the antibiotic binding site on the altered 50S ribosomal subunit is no longer accessible. We now report that certain 6-O-methyl-11,12-cyclic carbamate deriv...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Goldman, R C, Kadam, S K
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1989
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC176062/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2506804/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.33.7.1058
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