Formation of an adduct between fosfomycin and glutathione: a new mechanism of antibiotic resistance in bacteria.
Plasmid-borne resistance to fosfomycin in bacteria is due to modification of the antibiotic molecule by a glutathione S-transferase that catalyzes the formation of a covalent bond between the sulfhydryl residue of the cysteine in glutathione and the C-1 of fosfomycin. This reaction results in openin...
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| Publicado no: | Antimicrob Agents Chemother |
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| Principais autores: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
1988
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175917/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3056239/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.32.10.1552 |
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