Formation of an adduct between fosfomycin and glutathione: a new mechanism of antibiotic resistance in bacteria.

Plasmid-borne resistance to fosfomycin in bacteria is due to modification of the antibiotic molecule by a glutathione S-transferase that catalyzes the formation of a covalent bond between the sulfhydryl residue of the cysteine in glutathione and the C-1 of fosfomycin. This reaction results in openin...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Arca, P, Rico, M, Braña, A F, Villar, C J, Hardisson, C, Suárez, J E
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1988
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175917/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3056239/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.32.10.1552
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