A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling

Oxidative stress and mitochondrial dysfunction are associated with disease and aging. Oxidative stress results from overproduction of reactive oxygen species (ROS), often leading to peroxidation of membrane phospholipids and production of reactive aldehydes, particularly 4-hydroxy-2-nonenal. Mild un...

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Main Authors: Echtay, Karim S., Esteves, Telma C., Pakay, Julian L., Jekabsons, Mika B., Lambert, Adrian J., Portero-Otín, Manuel, Pamplona, Reinald, Vidal-Puig, Antonio J., Wang, Steven, Roebuck, Stephen J., Brand, Martin D.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC175801/
https://ncbi.nlm.nih.gov/pubmed/12912909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg412
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