GCNF-dependent repression of BMP-15 and GDF-9 mediates gamete regulation of female fertility

To determine the function of germ cell nuclear factor (GCNF) in female reproduction, we generated an oocyte-specific GCNF knockout mouse model (GCNF(fl/fl)Zp3Cre(+)). These mice displayed hypofertility due to prolonged diestrus phase of the estrous cycle and aberrant steroidogenesis. These reproduct...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Lan, Zi-Jian, Gu, Peili, Xu, Xueping, Jackson, Kathy J., DeMayo, Francesco J., O’Malley, Bert W., Cooney, Austin J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2003
Assuntos:	Articles
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175795/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12912906/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg405
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