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Disruption of one intra-chain disulphide bond in the carboxyl-terminal propeptide of the proα1(I) chain of type I procollagen permits slow assembly and secretion of overmodified, but stable procollagen trimers and results in mild osteogenesis imperfecta
Type I procollagen is a heterotrimer comprised of two proα1(I) chains and one proα2(I) chain. Chain recognition, association, and alignment of proα chains into correct registration are thought to occur through interactions between the C-terminal propeptide domains of the three chains. The C-propepti...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMJ Group
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1757177/ https://ncbi.nlm.nih.gov/pubmed/11432962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.38.7.443 |
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