Induction of an immune response by oral administration of recombinant botulinum toxin.
A gene encoding the full-size botulinum neurotoxin serotype C was reconstructed in vector pQE-30 and expressed at high levels in Escherichia coli. Three amino acid mutations (H229-->G, E230-->T, and H233-->N) were generated in the zinc-binding motif, resulting in complete detoxification of the modif...
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| Udgivet i: | Infect Immun |
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| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
1997
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175658/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9353037/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.65.11.4586-4591.1997 |
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