Induction of an immune response by oral administration of recombinant botulinum toxin.

A gene encoding the full-size botulinum neurotoxin serotype C was reconstructed in vector pQE-30 and expressed at high levels in Escherichia coli. Three amino acid mutations (H229-->G, E230-->T, and H233-->N) were generated in the zinc-binding motif, resulting in complete detoxification of...

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Main Authors: Kiyatkin, N, Maksymowych, A B, Simpson, L L
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC175658/
https://ncbi.nlm.nih.gov/pubmed/9353037
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