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Differential effects of leflunomide and methotrexate on cytokine production in rheumatoid arthritis

Background: T cells have a pivotal role in RA. Leflunomide inhibits pyrimidine biosynthesis, to which T cells are especially susceptible, and therefore may have a different cytokine profile than methotrexate. Materials and methods: Serum samples of 100 patients with RA, treated with leflunomide (n =...

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Main Authors: Kraan, M, Smeets, T, van Loon, M J, Breedveld, F, Dijkmans, B, Tak, P
Format: Artigo
Jezik:Inglês
Izdano: 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1755136/
https://ncbi.nlm.nih.gov/pubmed/15115713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2003.014738
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