Simvastatin reduces MMP-3 level in interleukin 1ß stimulated human chondrocyte culture

Objectives: Matrix metalloproteinases (MMPs) produced by chondrocytes play a role in the development of cartilage degradation in joint diseases. Moreover, inhibition of MMP secretion by macrophages accumulating in arteriosclerotic plaques would account for the plaque stabilising activity of statins...

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Detalhes bibliográficos
Main Authors: Lazzerini, P, Capecchi, P, Nerucci, F, Fioravanti, A, Chellini, F, Piccini, M, Bisogno, S, Marcolongo, R, Laghi, P
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Extended Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1755052/
https://ncbi.nlm.nih.gov/pubmed/15194586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2003.009746
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