Development of sulfasalazine resistance in human T cells induces expression of the multidrug resistance transporter ABCG2 (BCRP) and augmented production of TNFα

Objective: To determine whether overexpression of cell membrane associated drug efflux pumps belonging to the family of ATP binding cassette (ABC) proteins contributes to a diminished efficacy of sulfasalazine (SSZ) after prolonged cellular exposure to this disease modifying antirheumatic drug (DMAR...

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Detalhes bibliográficos
Main Authors: van der Heijden, J, de Jong, M C, Dijkmans, B, Lems, W, Oerlemans, R, Kathmann, I, Schalkwijk, C, Scheffer, G, Scheper, R, Jansen, G
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Extended Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1754889/
https://ncbi.nlm.nih.gov/pubmed/14722201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2002.005249
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