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Inhibition of leukotriene B(4)-induced CD11B/CD18 (Mac-1) expression by BIIL 284, a new long acting LTB(4) receptor antagonist, in patients with rheumatoid arthritis

Background: Leukotriene B4 (LTB(4)) has a key role in the pathophysiology of rheumatoid arthritis (RA). Objective: To investigate the inhibition of ex vivo LTB(4)-induced Mac-1 (CD11b/CD18) expression in leucocytes of patients with RA by the new oral LTB(4) receptor antagonist BIIL 284. Methods: The...

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Detalhes bibliográficos
Main Authors: Alten, R, Gromnica-Ihle, E, Pohl, C, Emmerich, J, Steffgen, J, Roscher, R, Sigmund, R, Schmolke, B, Steinmann, G
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1754875/
https://ncbi.nlm.nih.gov/pubmed/14722206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2002.004499
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