A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen.

Several bacterial protein toxins require activation by eukaryotic proteases. Previous studies have shown that anthrax toxin protective antigen (PA), Pseudomonas exotoxin A (PE), and diphtheria toxin (DT) are cleaved by furin C-terminal to the sequences RKKR, RQPR, and RVRR, respectively. Because fur...

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Detalles Bibliográficos

Publicado en:	Infect Immun
Principais autores:	Gordon, V M, Rehemtulla, A, Leppla, S H
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175476/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9234799/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.65.8.3370-3375.1997
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