A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen.

Several bacterial protein toxins require activation by eukaryotic proteases. Previous studies have shown that anthrax toxin protective antigen (PA), Pseudomonas exotoxin A (PE), and diphtheria toxin (DT) are cleaved by furin C-terminal to the sequences RKKR, RQPR, and RVRR, respectively. Because fur...

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Pubblicato in:	Infect Immun
Autori principali:	Gordon, V M, Rehemtulla, A, Leppla, S H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175476/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9234799/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.65.8.3370-3375.1997
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