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Active leflunomide metabolite inhibits interleukin 1ß, tumour necrosis factor α, nitric oxide, and metalloproteinase-3 production in activated human synovial tissue cultures
Background: Leflunomide is now an approved agent for the management of adult rheumatoid arthritis (RA). Its active metabolite A771726 inhibits de novo pyrimidine biosynthesis. Although considered to be an immunosuppressive agent, its mechanism of action remains obscure. Objectives: Evaluation of the...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1754531/ https://ncbi.nlm.nih.gov/pubmed/12695157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.62.5.440 |
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