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Lifelong voluntary joint loading increases osteoarthritis in mice housing a deletion mutation in type II procollagen gene, and slightly also in non-transgenic mice

Objectives: To investigate the effects of voluntary running on the incidence and severity of osteoarthritis (OA) and associated changes in cartilage matrix and subchondral bone in a transgenic Del1 mouse model for OA. Methods: Del1 mice and their non-transgenic littermate controls were housed from t...

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Bibliografische gegevens
Hoofdauteurs: Lapvetelainen, T, Hyttinen, M, Saamanen, A, Langsjo, T, Sahlman, J, Felszeghy, S, Vuorio, E, Helminen, H
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2002
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1754230/
https://ncbi.nlm.nih.gov/pubmed/12176806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.61.9.810
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