Intranasal immunogenicity and adjuvanticity of site-directed mutant derivatives of cholera toxin.

Genetically modified derivatives of cholera toxin (CT), harboring a single amino acid substitution in and around the NAD binding cleft of the A subunit, were isolated following site-directed mutagenesis of the ctxA gene. Two mutants of CT, designated CTS106 (with a proline-to-serine change at positi...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Douce, G, Fontana, M, Pizza, M, Rappuoli, R, Dougan, G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175397/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9199455/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.65.7.2821-2828.1997
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