Basic calcium phosphate crystals activate human osteoarthritic synovial fibroblasts and induce matrix metalloproteinase-13 (collagenase-3) in adult porcine articular chondrocytes

OBJECTIVE—To determine the ability of basic calcium phosphate (BCP) crystals to induce (a) mitogenesis, matrix metalloproteinase (MMP)-1, and MMP-13 in human osteoarthritic synovial fibroblasts (HOAS) and (b) MMP-13 in cultured porcine articular chondrocytes.
METHODS—Mitogenesis of HOAS was measured...

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Detalhes bibliográficos
Main Authors: McCarthy, G, Westfall, P, Masuda, I, Christopherson, P, Cheung, H, Mitchell, P
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
Assuntos:
Extended Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1753595/
https://ncbi.nlm.nih.gov/pubmed/11247873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.60.4.399
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