Insulin-like growth factor 1 blocks collagen release and down regulates matrix metalloproteinase-1, -3, -8, and -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin M in combination with interleukin 1α

OBJECTIVE—To investigate the effect of insulin-like growth factor 1 (IGF1) on the release of collagen, and the production and expression of matrix metalloproteinases (MMPs) induced by the proinflammatory cytokine interleukin 1α (IL1α) in combination with oncostatin M (OSM) from bovine nasal cartilag...

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Bibliographic Details
Main Authors: Hui, W, Rowan, A, Cawston, T
Format: Artigo
Language:Inglês
Published: 2001
Subjects:
Extended Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1753584/
https://ncbi.nlm.nih.gov/pubmed/11171688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.60.3.254
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