Inactivation of one allele of the type II collagen gene alters the collagen network in murine articular cartilage and makes cartilage softer

OBJECTIVE—To evaluate the influence of inactivation of one allele ("heterozygous knockout" or "heterozygous inactivation") of the type II procollagen gene (Col2a1) on the biomechanical properties and structure of the articular cartilage and subchondral bone in 15( )month old mice...

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Detalles Bibliográficos
Main Authors: Hyttinen, M, Toyras, J, Lapvetelainen, T, Lindblom, J, Prockop, D, Li, S, Arita, M, Jurvelin, J, Helminen, H
Formato: Artigo
Idioma:Inglês
Publicado: 2001
Assuntos:
Extended Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1753566/
https://ncbi.nlm.nih.gov/pubmed/11171689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.60.3.262
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