Elevation of vacuolar pH inhibits the cytotoxic activity of furin-cleaved exotoxin A.
Exotoxin A (ETA) inhibits protein synthesis in cells by a process that involves receptor-mediated endocytosis and the transport of a 37-kDa proteolytic fragment across a membrane into the cytoplasm. The fragment is apparently generated by the endoprotease furin after the toxin has been endocytosed....
Gespeichert in:
| Veröffentlicht in: | Infect Immun |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology (ASM)
1997
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175309/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9169757/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.65.6.2240-2242.1997 |
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