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Mechanism of action of benzodiazepines on GABA(A) receptors

1. Wild-type and mutant α1β2γ2 GABA(A) receptors were expressed in Xenopus laevis oocytes and examined using the two-electrode voltage clamp. 2. Dose–response relationships for GABA were compared in the absence and presence of 1 μM diazepam (DZP) or methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carb...

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Autori principali: Campo-Soria, Claudia, Chang, Yongchang, Weiss, David S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751932/
https://ncbi.nlm.nih.gov/pubmed/16783415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706796
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