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Na(+)–K(+)–2Cl(−) cotransporter is implicated in gender differences in the response of the rat aorta to phenylephrine

1. Inhibition of the Na(+)–K(+)–2Cl(−) cotransporter (NKCC1) with bumetanide reduced contractile responses to phenylephrine (PE) in male rat aortas (129±4% of 60 mM KCl-induced contraction control vs 108±7% bumetanide; PE 10(−5) M; P<0.01) but did not change equivalent responses in female rat aor...

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Detalhes bibliográficos
Main Authors: Palacios, Javier, Espinoza, Francisco, Munita, Carolina, Cifuentes, Fredi, Michea, Luis
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751927/
https://ncbi.nlm.nih.gov/pubmed/16799647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706818
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