Cardioprotective effects of atrasentan, an endothelin-A receptor antagonist, but not of nitric oxide in diabetic mice with myocyte-specific overexpression of endothelial nitric oxide synthase

1. We investigated the roles of nitric oxide (NO) and endothelin-1 (ET-1) in organ dysfunction in diabetic mice with normal genotype (wild-type, WT) or myocyte-specific overexpression of endothelial NO synthase (eNOS) (transgenic, TG) after chronic oral treatment with the endothelin-A (ET(A)) recept...

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Detalhes bibliográficos
Main Authors: Wölkart, Gerald, Stessel, Heike, Saad, Zora, Kirchengast, Michael, Brunner, Friedrich
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751871/
https://ncbi.nlm.nih.gov/pubmed/16702986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706772
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