Enzymatic pathways involved in the generation of endothelin-1(1–31) from exogenous big endothelin-1 in the rabbit aorta

1. We investigated whether blood vessels contribute to the production of ET-1(1–31) from exogenous big endothelin-1 (BigET-1) in the rabbit and assessed which enzymes are involved in this process. 2. Vascular reactivity experiments, using standard muscle bath procedures, showed that BigET-1 induces...

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Main Authors: Tirapelli, Carlos R, Fecteau, Marie-Helene, Honore, Jean-Claude, Legros, Eurode, Gobeil, Fernand, D'orleans-Juste, Pedro
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2006
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Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751794/
https://ncbi.nlm.nih.gov/pubmed/16633356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706735
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