Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons

1. Aminoglutethimide is a clinically available drug that suppresses steroid biosynthesis by inhibiting enzymes such as cytochrome P450scc and aromatase. Because several members of neurosteroids regulate glutamate receptors, we investigated the effect of aminoglutethimide on cell death induced by ove...

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Bibliographic Details
Main Authors: Shirakawa, Hisashi, Katsuki, Hiroshi, Kume, Toshiaki, Kaneko, Shuji, Akaike, Akinori
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2006
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751506/
https://ncbi.nlm.nih.gov/pubmed/16474421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706636
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