Effects of overexpression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis.

Mutations to the regulatory region of the ahpC gene, resulting in overproduction of alkyl hydroperoxide reductase, were encountered frequently in a large collection of isoniazid (INH)-resistant clinical isolates of Mycobacterium tuberculosis but not in INH-susceptible strains. Overexpression of ahpC...

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Hauptverfasser: Heym, B, Stavropoulos, E, Honoré, N, Domenech, P, Saint-Joanis, B, Wilson, T M, Collins, D M, Colston, M J, Cole, S T
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1997
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC175145/
https://ncbi.nlm.nih.gov/pubmed/9119479
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