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pH-Dependence of Extrinsic and Intrinsic H(+)-Ion Mobility in the Rat Ventricular Myocyte, Investigated Using Flash Photolysis of a Caged-H(+) Compound

Passive H(+)-ion mobility within eukaryotic cells is low, due to H(+)-ion binding to cytoplasmic buffers. A localized intracellular acidosis can therefore persist for seconds or even minutes. Because H(+)-ions modulate so many biological processes, spatial intracellular pH (pH(i))-regulation becomes...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Swietach, Pawel, Spitzer, Kenneth W., Vaughan-Jones, Richard D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Biophysical Society 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751406/
https://ncbi.nlm.nih.gov/pubmed/17056723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.096560
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