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Gender differences in the slow delayed (I(Ks)) but not in inward (I(K1)) rectifier K(+) currents of canine Purkinje fibre cardiac action potential: key roles for I(Ks), β-adrenoceptor stimulation, pacing rate and gender

1. As the beagle dog is a commonly used preclinical species to test the effects of new drugs on cardiac repolarisation and Purkinje fibres have become an established in vitro preparation to assess the effects of these new drugs on action potential duration (APD), the main aim of this study was there...

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Detalhes bibliográficos
Main Authors: Abi-Gerges, Najah, Small, Ben G, Lawrence, Chris L, Hammond, Tim G, Valentin, Jean-Pierre, Pollard, Chris E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751338/
https://ncbi.nlm.nih.gov/pubmed/16314855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706491
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