Substrate Selectivity of Epidermal Growth Factor-Receptor Ligand Sheddases and their Regulation by Phorbol Esters and Calcium Influx

Signaling via the epidermal growth factor receptor (EGFR), which has critical roles in development and diseases such as cancer, is regulated by proteolytic shedding of its membrane-tethered ligands. Sheddases for EGFR-ligands are therefore key signaling switches in the EGFR pathway. Here, we determi...

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Bibliografski detalji
Glavni autori: Horiuchi, Keisuke, Le Gall, Sylvain, Schulte, Marc, Yamaguchi, Takafumi, Reiss, Karina, Murphy, Gillian, Toyama, Yoshiaki, Hartmann, Dieter, Saftig, Paul, Blobel, Carl P.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2007
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Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751309/
https://ncbi.nlm.nih.gov/pubmed/17079736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-01-0014
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