Production of interleukin-8 (IL-8) by cultured endothelial cells in response to Borrelia burgdorferi occurs independently of secreted [corrected] IL-1 and tumor necrosis factor alpha and is required for subsequent transendothelial migration of neutrophils.

Previous studies have shown that Borrelia burgdorferi, the spirochetal agent of Lyme disease, promotes inflammation by stimulating endothelial cells to upregulate adhesion molecules for leukocytes and to produce a soluble agent that is chemotactic for neutrophils. We determined that interleukin-8 (I...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Burns, M J, Sellati, T J, Teng, E I, Furie, M B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175120/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9119454/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.65.4.1217-1222.1997
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