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Neutrophils and the kallikrein–kinin system in proteinase-activated receptor 4-mediated inflammation in rodents

1. We evaluated a potential role for proteinase-activated receptor 4 (PAR(4)) in a rodent paw inflammation model, with a focus on two main features of inflammation: (1) oedema and (2) granulocyte recruitment. 2. A PAR(4) antagonist (Pepducin P4pal-10; palmitoyl-SGRRYGHALR-NH(2)) reduced both the oed...

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Detalhes bibliográficos
Main Authors: Houle, Steeve, Papez, Martin D, Ferazzini, Mara, Hollenberg, Morley D, Vergnolle, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751199/
https://ncbi.nlm.nih.gov/pubmed/16100525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706371
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