Mechanism of allosteric regulation of transglutaminase 2 by GTP

Allosteric regulation is a fundamental mechanism of biological control. Here, we investigated the allosteric mechanism by which GTP inhibits cross-linking activity of transglutaminase 2 (TG2), a multifunctional protein, with postulated roles in receptor signaling, extracellular matrix assembly, and...

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Detalles Bibliográficos
Main Authors: Begg, Gillian E., Carrington, Lyle, Stokes, Philippa H., Matthews, Jacqueline M., Wouters, Merridee A., Husain, Ahsan, Lorand, Laszlo, Iismaa, Siiri E., Graham, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1750866/
https://ncbi.nlm.nih.gov/pubmed/17179049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609283103
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