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Antagonism of wild-type and resistant Escherichia coli and its DNA gyrase by the tricyclic 4-quinolone analogs ofloxacin and S-25930 stereoisomers.

The mechanism of action of the quinolone analogs ofloxacin and S-25930, which are unusual because of the presence of a third ring with an asymmetric carbon, was studied. Drug-resistant strains of Escherichia coli were selected by serial passage in the presence of ofloxacin, and a mutation was mapped...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Wolfson, J S, Hooper, D C, Ng, E Y, Souza, K S, McHugh, G L, Swartz, M N
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1987
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175056/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2829717/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.11.1861
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