Antagonism of wild-type and resistant Escherichia coli and its DNA gyrase by the tricyclic 4-quinolone analogs ofloxacin and S-25930 stereoisomers.

The mechanism of action of the quinolone analogs ofloxacin and S-25930, which are unusual because of the presence of a third ring with an asymmetric carbon, was studied. Drug-resistant strains of Escherichia coli were selected by serial passage in the presence of ofloxacin, and a mutation was mapped...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Wolfson, J S, Hooper, D C, Ng, E Y, Souza, K S, McHugh, G L, Swartz, M N
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1987
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175056/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2829717/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.11.1861
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