Comparative in vitro and in vivo evaluation of N-D-ornithyl amphotericin B methyl ester, amphotericin B methyl ester, and amphotericin B.

N-D-Ornithyl amphotericin B methyl ester (O-AME), a semisynthetic derivative of amphotericin B methyl ester (AME), was compared with amphotericin B (AMB) and AME. In vitro, O-AME was more active than the other two against Candida spp. and other fungi and was only slightly affected by inoculum size,...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Parmegiani, R M, Loebenberg, D, Antonacci, B, Yarosh-Tomaine, T, Scupp, R, Wright, J J, Chiu, P J, Miller, G H
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1987
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175034/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3324961/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.11.1756
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