Comparative in vitro and in vivo evaluation of N-D-ornithyl amphotericin B methyl ester, amphotericin B methyl ester, and amphotericin B.

N-D-Ornithyl amphotericin B methyl ester (O-AME), a semisynthetic derivative of amphotericin B methyl ester (AME), was compared with amphotericin B (AMB) and AME. In vitro, O-AME was more active than the other two against Candida spp. and other fungi and was only slightly affected by inoculum size,...

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Autores principales: Parmegiani, R M, Loebenberg, D, Antonacci, B, Yarosh-Tomaine, T, Scupp, R, Wright, J J, Chiu, P J, Miller, G H
Formato: Artigo
Lenguaje:Inglês
Publicado: 1987
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC175034/
https://ncbi.nlm.nih.gov/pubmed/3324961
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