Novel pyrazolo[3,4-d]pyrimidine nucleoside analog with broad-spectrum antiviral activity.

A novel nucleoside analog, 4(5H)-oxo-1-beta-D- ribofuranosylpyrazolo[3,4-d]pyrimidine-3-thiocarboxamide (N10169), was evaluated in cell culture and in animals for antiviral activity against DNA and RNA viruses. The compound was highly active against strains of adeno-, vaccinia, influenza B, paramyxo...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Smee, D F, McKernan, P A, Nord, L D, Willis, R C, Petrie, C R, Riley, T M, Revankar, G R, Robins, R K, Smith, R A
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1987
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174985/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3435102/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.10.1535
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