Improved sensitivity in assays for binding of novel beta-lactam antibiotics to penicillin-binding proteins of Escherichia coli.

Tigemonam and temocillin, but not aztreonam, bound to penicillin-binding proteins (PBPs) 1a and 3 of Escherichia coli with apparent improved affinity when challenged with benzylpenicillin at lowered temperatures. Half times for deacylation of the tigemonam-PBP complexes were shorter than were those...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Bush, K, Smith, S A, Ohringer, S, Tanaka, S K, Bonner, D P
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1987
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174917/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3307621/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.8.1271
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