Evaluation of (+)-cyclaradine-5'-esters as prodrugs for (+)-cyclaradine in animals.

Both (+)-cyclaradine-5'-methoxyacetate (CM) and (+)-cyclaradine-5'-ethoxypropionate (CE) were converted to (+)-cyclaradine (C) in squirrel monkey and human sera at 37 degrees C. CE was more stable than CM. After oral administration (20 mg base equivalent per kg) of either CM or CE, no unch...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Lim, J, Schwartz, J, Loebenberg, D, Miller, G H, Symchowicz, S, Lin, C
Format: Artigo
Langue:Inglês
Publié: 1987
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC174859/
https://ncbi.nlm.nih.gov/pubmed/3662479
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