Evaluation of (+)-cyclaradine-5'-esters as prodrugs for (+)-cyclaradine in animals.

Both (+)-cyclaradine-5'-methoxyacetate (CM) and (+)-cyclaradine-5'-ethoxypropionate (CE) were converted to (+)-cyclaradine (C) in squirrel monkey and human sera at 37 degrees C. CE was more stable than CM. After oral administration (20 mg base equivalent per kg) of either CM or CE, no unch...

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Detalhes bibliográficos
Main Authors: Lim, J, Schwartz, J, Loebenberg, D, Miller, G H, Symchowicz, S, Lin, C
Formato: Artigo
Idioma:Inglês
Publicado em: 1987
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC174859/
https://ncbi.nlm.nih.gov/pubmed/3662479
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