Presenilin mutations linked to familial Alzheimer's disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolism

Phosphatidylinositol 4,5-bisphosphate (PIP(2)) is an important cellular effector whose functions include the regulation of ion channels and membrane trafficking. Aberrant PIP(2) metabolism has also been implicated in a variety of human disease states, e.g., cancer and diabetes. Here we report that f...

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Autori principali: Landman, Natalie, Jeong, Soon Youn, Shin, Sun Young, Voronov, Sergey V., Serban, Geo, Kang, Min Suk, Park, Myung Kyu, Di Paolo, Gilbert, Chung, Sungkwon, Kim, Tae-Wan
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1748258/
https://ncbi.nlm.nih.gov/pubmed/17158800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604954103
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