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Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding
The endosomal sorting complex ESCRT-III, which is formed by the structurally related CHMP proteins, is engaged by HIV-1 to promote viral budding. Here we show that progressive truncations into the C-terminal acidic domains of CHMP proteins trigger an increasingly robust anti-HIV budding activity. To...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1748189/ https://ncbi.nlm.nih.gov/pubmed/17146056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603788103 |
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