Correlation between renal membrane binding and nephrotoxicity of aminoglycosides.

The kinetics of aminoglycoside binding to renal brush border and basolateral membrane vesicles from rat renal cortex were studied by using [3H]amikacin. [3H]amikacin binding to renal membranes was found to be a rapid, saturable process with a fourfold greater affinity for basolateral membranes than...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Williams, P D, Bennett, D B, Gleason, C R, Hottendorf, G H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1987
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174778/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3606061/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.4.570
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