Demonstration of viral thymidine kinase inhibitor and its effect on deoxynucleotide metabolism in cells infected with herpes simplex virus.

The thymidine analog 5'-ethynylthymidine was a potent inhibitor of herpes simplex virus type 1 (strain KOS)-induced thymidine kinase with a Ki value of 0.09 microM. 5'-Ethynylthymidine was less inhibitory against herpes simplex virus type 2 (strain 333)-induced thymidine kinase with a Ki of 0.38 mic...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Nutter, L M, Grill, S P, Dutschman, G E, Sharma, R A, Bobek, M, Cheng, Y C
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1987
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174734/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3034143/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.3.368
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