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Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells

Background: A common pathological feature of chronic inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease (COPD) is mucus hypersecretion. MUC5AC is the predominant mucin gene expressed in healthy airways and is increased in asthmatic and COPD patients. Recent clinica...

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Detalhes bibliográficos
Main Authors: Mata, M, Sarria, B, Buenestado, A, Cortijo, J, Cerda, M, Morcillo, E
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1747298/
https://ncbi.nlm.nih.gov/pubmed/15681504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thx.2004.025692
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