Inhibition of DNA gyrase by optically active ofloxacin.

Inhibition of DNA gyrase activity by optically active ofloxacins was studied and compared with the inhibition of norfloxacin and ciprofloxacin. The (-)-isomer of ofloxacin inhibited the supercoiling activity of gyrase from Micrococcus luteus more effectively than did the (+)-isomer. The 50% inhibito...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Imamura, M, Shibamura, S, Hayakawa, I, Osada, Y
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1987
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174716/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3032098/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.2.325
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