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Decreased bronchodilating effect of salbutamol in relieving methacholine induced moderate to severe bronchoconstriction during high dose treatment with long acting β(2) agonists

BACKGROUND—In vitro the long acting β(2) agonist salmeterol can, in contrast to formoterol, behave as a partial agonist and become a partial antagonist to other β(2) agonists. To study this in vivo, the bronchodilating effect of salbutamol was measured during methacholine induced moderate to severe...

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Hlavní autoři: van der Woude, H J, Winter, T, Aalbers, R
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Group 2001
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1746085/
https://ncbi.nlm.nih.gov/pubmed/11413351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thorax.56.7.529
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